Linear 1 3-diarylpropanoids
Medchemexpress LLC Pinostrobin chalcone | 18956-15-5 | 1 MG
Pinostrobin chalcone is a potent natural cytotoxic compound, demonstrating efficacy against MDA-MB-231 and HT-29 colon cancer cell lines with IC50 values of 20.42±2.23 and 22.51±0.42 μg/mL, respectively. This product is intended for research use only.
- Purity: 99.94%
- Molecular weight: 270.28
- Formula: C16H14O4
- Appearance: Solid
- Color: Light yellow to orange
- Structure classification: Flavonoids, chalcones, phenols, polyphenols
- Initial source: Plants, Leguminosae, Cajanus cajan (L.) Millsp.
- Exhibits anti-inflammatory activity against mouse J774.A1 cells
- Shows anti-inflammatory activity against mouse RAW264.7 cells
- Tested for antiproliferative activity against MCF-7 human breast cancer cells
![eMolecules 480-41-1 | (S)-5,7-Dihydroxy-2-(4-hydroxyphenyl)chroman-4-one | AA Blocks LLC | MFCD00870553 | 272.256 | C15H12O5 | 0.000 | Oc1ccc(cc1)[C@@H]1CC(=O)c2c(O)cc(O)cc2O1 | 5g | 489792953](https://assets.fishersci.com/TFS-Assets/CCG/product-images/NC3966901.jpg-250.jpg)
eMolecules 480-41-1 | (S)-5,7-Dihydroxy-2-(4-hydroxyphenyl)chroman-4-one | AA Blocks LLC | MFCD00870553 | 272.256 | C15H12O5 | 0.000 | Oc1ccc(cc1)[C@@H]1CC(=O)c2c(O)cc(O)cc2O1 | 5g | 489792953
(S)-5,7-Dihydroxy-2-(4-hydroxyphenyl)chroman-4-one | AA Blocks LLC | 480-41-1 | MFCD00870553 | 272.256 | C15H12O5 | 0.000 | Oc1ccc(cc1)[C@@H]1CC(=O)c2c(O)cc(O)cc2O1 | 5g | 489792953
Medchemexpress LLC AKT inhibitor VIII | 612847-09-3 | MFCD23843802 | 99.0% | 551.64 g/mol | C34H29N7O | 100 MG
AKT inhibitor VIII is a cell-permeable, reversible allosteric inhibitor of Akt kinases used as a research reagent to probe PI3K/Akt signaling pathways. It is supplied as a light yellow solid for laboratory use.
- Allosteric, reversible Akt inhibitor.
- Isoform-selective activity with greater potency for Akt1 and Akt2.
- Reported IC50 values: Akt1 = 58 nM, Akt2 = 210 nM.
- Molecular formula C34H29N7O; molecular weight 551.64 g/mol.
- High reported purity (~99%).
- Supplied as a light yellow solid with recommended storage for powder at -20°C or 4°C depending on duration.
Medchemexpress LLC 2-propen-1-one, 1,3-diphenyl- | 94-41-7 | 100.0% | 100 MG
Chalcone is a small-molecule research chemical used as a synthetic intermediate and a reference compound in medicinal chemistry and biological assays. Offered in solid and solution formats, it is supplied with a certificate of analysis for batch verification.
- High purity suitable for analytical and synthetic work.
- Off-white to light yellow solid for easy handling.
- Soluble in DMSO at up to 100 mg/mL with sonication.
- Recommended storage for powder at -20°C for long-term stability.
- Certificate of analysis available for batch verification.
Medchemexpress LLC (E)-Naringenin chalcone | 25515-46-2 | 50 MG
(E)-Naringenin chalcone is an orally active anti-allergic agent. It also possesses antioxidant and anti-inflammatory activities, and can improve adipocyte functions.
- Inhibits histamine release from rat peritoneal mast cells
- Improves adipocyte functions by enhancing adiponectin production
- Stimulates PPARγ activity in NIH-3T3 cells
- Inhibits the production of TNF-alpha, MCP-1, and nitric oxide (NO) by LPS-stimulated RAW 264 macrophages
- Shows anti-allergic effect in type I allergic mice
- Suppresses allergic asthma by inhibiting the type-2 function of CD4 T cells
Medchemexpress LLC PI3K/AKT-IN-1 | 3033069-84-7 | 99.6% | C23H23N5O4S | 25 MG
PI3K/AKT-IN-1 is an effective dual inhibitor of PI3K and AKT, exhibiting anticancer activity by inhibiting the PI3K/AKT axis and inducing caspase 3-dependent apoptosis. This compound has high cytotoxic activity against leukemia K562 and breast cancer MCF-7 cell lines, and is intended for research use only.
- Demonstrates high cytotoxic activity, particularly against leukemia cell line K562 (IC50=2.62 μM) and breast cancer cell line MCF-7 (IC50=3.22 μM)
- Promotes S-phase cell cycle arrest and induces apoptosis in K562 cells
- Significantly reduces the expression of PI3K, p-PI3K, AKT, p-AKT, Cyclin D1, and NF-κB
- Found to be non-toxic and well-tolerated in animal studies, with an LD50 greater than 2000 mg/kg
- Soluble in DMSO at 50 mg/mL
- Solid, off-white to light yellow appearance
Medchemexpress LLC Naringenin | 480-41-1 | 99.3% | 272.25 | 1 G
Naringenin is the predominant flavanone found in *Citrus reticulata Blanco*. It exhibits strong anti-inflammatory and antioxidant activities, and also possesses anti-dengue virus (DENV) activity.
- Exhibits strong anti-inflammatory activity.
- Exhibits strong antioxidant activity.
- Possesses anti-dengue virus (DENV) activity.
- Inhibits HepG2 cell proliferation.
- Reduces plasma and liver triglycerides and cholesterol.
- Enhances hepatic fatty acid oxidation.
Medchemexpress LLC Chalcone 4 hydrate 1mg | 1202866-96-3 | ≈288.73 g/mol (anhydrous basis); varies with hydration (xH2O) | C16H13ClO3·xH2O | 1 MG
Chalcone 4 hydrate (CAS 1202866-96-3) is an anti-parasite small-molecule research reagent reported to inhibit the growth of Babesia and Theileria. The compound is supplied as a hydrated solid and is intended for in vitro parasitology and chemical biology studies; handle and store under recommended conditions.
- Hydrated solid form (xH2O)
- Purity 98.0%
- Molecular formula C16H13ClO3·xH2O
- Typical molecular weight ~288.73 g/mol (anhydrous basis)
- Offered in low-quantity research sizes (e.g., 1 mg)
- Store at 4°C; in solution, store -80°C up to 6 months or -20°C up to 1 month under nitrogen